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Clostridium difficile GDH+Toxin A+B Combo Rapid Test

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Clostridium difficile GDH+Toxin A+B Combo Rapid Test

A rapid test for the qualitative detection of Clostridium difficile Glutamate Dehydrogenase(GDH)Toxin A and Toxin B in feces.


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INTENDED USE 

The Clostridium difficile GDH+Toxin A+B Combo Rapid Test Cassette (Feces)is a rapid chromatographic immunoassay for the qualitative detection of Clostridium difficile Glutamate Dehydrogenase(GDH),Toxin A and Toxin B in feces.

SUMMARY  

Clostridia (members of the genus Clostridium) are anaerobic, motile bacteria, ubiquitous in nature,and especially prevalent in soil. Under the microscope, they appear as long, irregular (often drumstick- or spindle-shaped) cells with a bulge at their terminal ends. Under Gram staining,Clostridium difficile(C. difficile)cells are Gram-positive and show optimum growth on blood agar at human body temperatures in the absence of oxygen. When stressed, the bacteria produce spores that are able to tolerate extreme conditions that the active bacteria cannot tolerate. Clostridium difficile infection is associated with broad-spectrum antibiotic therapy and is the most common cause of infectious diarrhea in hospital patients. Pathogenic strains of C. difficile produce two protein exotoxins, toxin A and toxin B, which cause colonic mucosal injury and inflammation. C. difficile may become established in the human colon; 1,2,3 it is present in 2–5% of the adult population.

DIRECTIONS FOR USE  

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