【ZVIRI KUSHANDISA】

The Cotinine Rapid Test Strip/Card/Device inonzi lateral flow chromatographic immunoassay yekuona Cotinine muweti yemunhu panguva yakachekwa - off concentration ye200 ng/mL.Muedzo uyu uchaona mamwe makomboni ane hukama, tapota tarisa kutafura yeAnalytical Specificity iri pasuru ino.

Iyi assay inopa chete yekutanga analytical bvunzo mhinduro. Imwe nzira yakasarudzika yemakemikari inofanirwa kushandiswa kuitira kuwana yakasimbiswa yekuongorora mhedzisiro. Gasi chromatography uye mass spectrometry (GC/MS) ndiyo yakasarudzika nzira yekusimbisa. Kutariswa kwekiriniki uye kutonga kwehunyanzvi kunofanirwa kushandiswa kune chero mushonga wekushungurudzwa bvunzo mhinduro, kunyanya kana yekutanga mibairo yakanaka inoshandiswa.

【SUMMARY】

Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produce stimulation of the autonomic ganglia and central nervous system when in humans.Nicotine mushonga unovhenekerwa nenhengo yese yefodya-kusvuta kungave nekusangana chaiko kana kufemerwa neruoko. Pamusoro pefodya, chikakananda chinowanikwawo mukutengesa sechinhu chinoshanda mumishonga yekutsiva yekuputa senge nicotine chingamu, transdermal patches uye nasal sprays.

Muweti yeawa 24-awa, inenge 5% yechikakananda inobudiswa semushonga usina kuchinjwa ne10% secotinine uye 35% sehydroxycotinine; kuwanda kwemamwe metabolites anotendwa kuti anotora zvishoma pane 5%.1 Kunyange zvazvo cotinine ichifungidzirwa kuva metabolite isingashandiswi, iyo yekubvisa profiles yakanyanya kugadzikana kupfuura iyo nicotine iyo inonyanya kuve weti pH inotsamira.Nekuda kweizvozvo, cotinine inoonekwa seyakanaka biological marker yekusarudza nicotine kushandiswa. The plasma half-life of nicotine inenge maminetsi makumi matanhatu anotevera inhalation kana parenteral administration.2 Nicotine necotinine zvinokurumidza kubviswa neitsvo; hwindo rekuonekwa kwecotinine muweti padanho rekucheka re200 ng/mL rinotarisirwa kusvika ku2-3 mazuva mushure mekushandisa nicotine.

The Cotinine Rapid Test Strip/Card/Device inokurumidza weti yekuongorora bvunzo inogona kuitwa pasina kushandisa chiridzwa.Kuedza kunoshandisa monoclonal antibody kuti ione zvakanyanyisa mazinga eCotinine muweti.Cotinine Rapid Test Strip/Card/Device inobereka mhedzisiro yakanaka kana Cotinine inodarika 2L muweti.

【MAZANO EKUSHANDISA】

Bvumira bvunzo, weti yemuenzaniso, uye/kana zvidzoreso kusvika mukamuri tembiricha (15-30ºC) isati yaedzwa.

Yetest strip

1.Bvisa bvunzo Strip kubva muhomwe yakavharwa uye shandisa iyo nekukurumidza sezvinobvira.

2.Inyura mutsetse muweti sampuli nemuseve unoperera weti.

3.Usanyudza uchipfuura nemutsetse we“Maka”. Buritsa tambo mushure memasekonzi gumi woisa tambo yacho, yakafuratira panzvimbo yakachena, yakaoma, isingabviri kunyura (semuromo wemudziyo weti). Mirira kuti mutsara (mitsetse) ibude..Verenga zvawanikwa pamaminetsi mashanu paunenge uchiyedza muenzaniso.Usadudzire mhinduro mushure menguva yekuverenga yakakodzera.Zvakakosha kuti kumashure kuve kwakajeka mugumisiro usati waverengwa.

YeTest Card

1. Rongedza kadhi rekuyedza, kana tambo yekuyedza, zvienzaniso zveweti kana zvidzoreso zvekunze kune tembiricha yemumba(15-30°C) isati yaedzwa.

2. Kubvisa kadhi rekuedza kubva muhomwe yakavharwa uye kunyura kadhi mumuenzaniso kweinenge 15 seconds kusvika 20 seconds kana kusvika kutama kwaitika. Nyura chidimbu (ma) chekadhi rebvunzo pazasi pemutsara wepamusoro wemutsara wemasaisai pamitsetse yebvunzo; usanyike kadhi pamusoro pemutsara wepamusoro.

3. Isa kadhi rekuedza kana tambo yekuedza panzvimbo yakaoma yakaoma.

4. Verenga zvawanikwa pamaminetsi mashanu kusvika gumi.

Yekuedza mudziyo

1.Hunza homwe yacho mutembiricha yekamuri usati waivhura.Bvisa mudziyo wekuyedza kubva muhomwe yakavharwa uye uishandise nekukurumidza sezvinobvira.

2.Isa mudziyo wekuyedza panzvimbo yakachena uye yakadzikama.Bata chinodonhedza pasi uye wotamisa madonhwe matatu akazara eweti (approx.10ul) kumuenzaniso wematsime (S) echigadzirwa chekuedza, uye wobva watanga timer.Dzivisa kuteya mabhubhu emhepo mumuenzaniso zvakanaka (S) .Ona mufananidzo uri pasi apa.

3.Mirira kuti mutsara wemavara uoneke.Chigumisiro chinofanira kuverengwa pamaminitsi mashanu.Usadudzire chigumisiro mushure memaminitsi gumi.