Matenda a hepatitis B ndi matenda aakulu, ofooketsa omwe angayambitse matenda a chiwindi, khansa ya chiwindi ndi imfa. Matenda a hepatitis B ndi omwe amachititsa khansa ya chiwindi komanso chiwerengero cha khumi chomwe chimayambitsa imfa padziko lonse lapansi.Anthu ambiri amamenyana ndi matendawa okha, koma pafupifupi 5-10 peresenti ya omwe ali ndi kachilomboka amakhala onyamula, ndipo 5 - 10 peresenti yowonjezera ya omwe amadwala chaka chilichonse amapita ku matenda aakulu a chiwindi, matenda a cirrhosis ndipo mwina khansa ya chiwindi.